InterveXion Therapeutics reports that all subjects have completed all planned follow-up appointments in the first clinical study of ch-mAb7F9, the company’s first investigational anti-methamphetamine antibody product. Forty-two (42) non-METH using volunteer subjects were dosed with antibody or placebo in the study starting in May 2012. Because of the expected long duration of action of ch-mAb7F9, the subjects had safety assessments for the 21 weeks after ch-mAb7F9 dosing. No serious adverse events have been reported. Full safety and pharmacokinetic analyses should be complete by fall 2013. Preliminary and interim safety analyses (performed after each group was dosed) suggest that ch‑mAb7F9 is safe for human administration.
- InterveXion Therapeutics Announces Fast Track Designation of IXT-m200 for Treatment of Methamphetamine Addiction
- InterveXion Therapeutics, a UAMS Startup, Receives $14.5 Million to Develop Drug Therapies for Methamphetamine Users
- InterveXion publishes results of Phase 1a study of ch-mAb7F9
- Anti-METH Antibody Shortens the Time Rats are Affected by Repeated Doses of METH
- Two Anti-METH Antibodies Reduce METH-Induced Locomotor Effects and Favorably Alter METH Kinetics in Rats