Anti-Phencyclidine Monoclonal Antibody


Hubbard JJ, Laurenzana EM, Williams DK, Gentry WB, Owens SM. Chronic anti-phencyclidine monoclonal antibody therapy decreases phencyclidine-induced in utero fetal mortality in pregnant rats. Int Immunopharmacol. 2011 Dec;11(12):2181-7. PubMed PMID: 22001428; PubMed Central PMCID: PMC3285273.

Hubbard JJ, Laurenzana EM, Williams DK, Gentry WB, Owens SM. The fate and function of therapeutic anti-addiction monoclonal antibodies across the reproductive cycle of rats. J Pharmacol Exp Ther. 2011 Feb;336(2):414-22. PubMed PMID: 20962030; PubMed Central PMCID: PMC3033712.

Lacy HM, Gunnell MG, Laurenzana EM, Owens SM. Engineering and characterization of a mouse/human chimeric anti-phencyclidine monoclonal antibody. Int Immunopharmacol. 2008 Jan;8(1):1-11. PubMed PMID: 18068094; PubMed Central PMCID: PMC2238695.

Daniels JR, Wessinger WD, Hardwick WC, Li M, Gunnell MG, Hall CJ, Owens SM, McMillan DE. Effects of anti-phencyclidine and anti-(+)-methamphetamine monoclonal antibodies alone and in combination on the discrimination of phencyclidine and (+)-methamphetamine by pigeons. Psychopharmacology (Berl). 2006 Mar;185(1):36-44. PubMed PMID: 16479372.

Laurenzana EM, Gunnell MG, Gentry WB, Owens SM. Treatment of adverse effects of excessive phencyclidine exposure in rats with a minimal dose of monoclonal antibody. J Pharmacol Exp Ther. 2003 Sep;306(3):1092-8. PubMed PMID: 12829731.

Hardin JS, Wessinger WD, Wenger GR, Proksch JW, Laurenzana EM, Owens SM. A single dose of monoclonal anti-phencyclidine IgG offers long-term reductions in phencyclidine behavioral effects in rats. J Pharmacol Exp Ther. 2002 Jul;302(1):119-26. PubMed PMID: 12065708.

Proksch JW, Gentry WB, Owens SM. Anti-phencyclidine monoclonal antibodies provide long-term reductions in brain phencyclidine concentrations during chronic phencyclidine administration in rats. J Pharmacol Exp Ther. 2000 Mar;292(3):831-7. PubMed PMID: 10688594.

Proksch JW, Gentry WB, Owens SM. Pharmacokinetic mechanisms for obtaining high renal coelimination of phencyclidine and a monoclonal antiphencyclidine antigen-binding fragment of immunoglobulin G in the rat. J Pharmacol Exp Ther. 1998 Nov;287(2):616-24. PubMed PMID: 9808688.

Lim K, Owens SM, Arnold L, Sacchettini JC, Linthicum DS. Crystal structure of monoclonal 6B5 Fab complexed with phencyclidine. J Biol Chem. 1998 Oct 30;273(44):28576-82. PubMed PMID: 9786848.

Hardin JS, Wessinger WD, Proksch JW, Owens SM. Pharmacodynamics of a monoclonal antiphencyclidine Fab with broad selectivity for phencyclidine-like drugs. J Pharmacol Exp Ther. 1998 Jun;285(3):1113-22. PubMed PMID: 9618414.

Valentine JL, Owens SM. Antiphencyclidine monoclonal antibody therapy significantly changes phencyclidine concentrations in brain and other tissues in rats. J Pharmacol Exp Ther. 1996 Aug;278(2):717-24. PubMed PMID: 8768723.

Valentine JL, Mayersohn M, Wessinger WD, Arnold LW, Owens SM. Antiphencyclidine monoclonal Fab fragments reverse phencyclidine-induced behavioral effects and ataxia in rats. J Pharmacol Exp Ther. 1996 Aug;278(2):709-16. PubMed PMID: 8768722.

Valentine JL, Arnold LW, Owens SM. Anti-phencyclidine monoclonal Fab fragments markedly alter phencyclidine pharmacokinetics in rats. J Pharmacol Exp Ther. 1994 Jun;269(3):1079-85. PubMed PMID: 8014850.

McClurkan MB, Valentine JL, Arnold L, Owens SM. Disposition of a monoclonal anti-phencyclidine Fab fragment of immunoglobulin G in rats. J Pharmacol Exp Ther. 1993 Sep;266(3):1439-45. PubMed PMID: 8371148.

Egen NB, Bliss M, Mayersohn M, Owens SM, Arnold L, Bier M. Isolation of monoclonal antibodies to phencyclidine from ascites fluid by preparative isoelectric focusing in the Rotofor. Anal Biochem. 1988 Aug 1;172(2):488-94. PubMed PMID: 3189790.

Owens SM, Zorbas M, Lattin DL, Gunnell M, Polk M. Antibodies against arylcyclohexylamines and their similarities in binding specificity with the phencyclidine receptor. J Pharmacol Exp Ther. 1988 Aug;246(2):472-8. PubMed PMID: 2457075.